CAS NO: | 1881270-27-4 |
规格: | 98% |
分子量: | 324.4 |
包装 | 价格(元) |
500ug | 电议 |
1mg | 电议 |
5mg | 电议 |
Background:
CAY10706 is a ligustrazine-curcumin hybrid that promotes intracellular reactive oxygen species accumulation preferentially in lung cancer cells. It has been shown to inhibit the proliferation of drug-sensitive (A549 (IC50 = 2.19 µM), SPC-A-1 (IC50 = 3.12 µM), LTEP-G-2 (IC50 = 2.88 µM)) and drug-resistant (A549/DDP (IC50 = 0.6 µM)) lung cancer cells but demonstrates little effect on non-tumor lung epithelial-like cells (HBE (IC50 = 21.34 µM)). CAY10706 can suppress the thioredoxin reductase system and inhibit the NF-κB, Akt, and ERK signaling.