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CAY10706
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAY10706图片
CAS NO:1881270-27-4
规格:98%
分子量:324.4
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
CAY10706 is a ligustrazine-curcumin hybrid that promotes intracellular reactive oxygen species accumulation preferentially in lung cancer cells.
CAS:1881270-27-4
分子式:C19H20N2O3
分子量:324.4
纯度:98%
存储:Store at -20°C

Background:

CAY10706 is a ligustrazine-curcumin hybrid that promotes intracellular reactive oxygen species accumulation preferentially in lung cancer cells. It has been shown to inhibit the proliferation of drug-sensitive (A549 (IC50 = 2.19 µM), SPC-A-1 (IC50 = 3.12 µM), LTEP-G-2 (IC50 = 2.88 µM)) and drug-resistant (A549/DDP (IC50 = 0.6 µM)) lung cancer cells but demonstrates little effect on non-tumor lung epithelial-like cells (HBE (IC50 = 21.34 µM)). CAY10706 can suppress the thioredoxin reductase system and inhibit the NF-κB, Akt, and ERK signaling.