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NS309
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NS309图片
CAS NO:18711-16-5
规格:98%
分子量:231.04
包装与价格:
包装价格(元)
5mg电议
50mg电议

产品介绍
Calcium-Activated Potassium Channel activator
CAS:18711-16-5
分子式:C8H4Cl2N2O2
分子量:231.04
纯度:98%
存储:Store at -20°C

Background:

NS309 is a positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels); increases Ca2+ sensitivity. Displays no activity at BK channels.IC50 value: Ca2+-activated K+ channelTarget:


参考文献:
[1]. Stankevicius, Edgaras; Dalsgaard, Thomas; Kroigaard, Christel et al. Opening of small and intermediate calcium-activated potassium channels induces relaxation mainly mediated by nitric-oxide release in large arteries and endothelium-derived hyperpolarizin
[2]. Seear, Rachel V.; Lew, Virgilio L. IKCa agonist (NS309)-elicited all-or-none dehydration response of human red blood cells is cell-age dependent. Cell Calcium (2011), 50(5), 444-448.
[3]. Dalsgaard, T.; Kroigaard, C.; Misfeldt, M. Openers of small conductance calcium-activated potassium channels selectively enhance NO-mediated bradykinin vasodilatation in porcine retinal arterioles. British Journal of Pharmacology (2010), 160(6), 1496-1508
[4]. Broendum, E.; Kold-Petersen, H.; Simonsen, U.; Aalkjaer, C. NS309 restores EDHF-type relaxation in mesenteric small arteries from type 2 diabetic ZDF rats. British Journal of Pharmacology (2010), 159(1), 154-165.