R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI).
CAS：338773-13-0
分子式：C16H8ClF3N4
分子量：348.7
纯度：98%
存储：Store at -20°C

Background:

R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI). It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-α and IL-1β with EC50 values of 2.45 and 3.79 µM, respectively, in an ELISA using A549 lung epithelial cells.{|Gururaja2007|} It also disrupts the interaction of the TNF-αRI with receptor interacting protein 1 (RIP1) and TNF-αR-associated death domain protein (TRADD), preventing internalization of the receptor complex.