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KU-0060648
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
KU-0060648图片
CAS NO:881375-00-4
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件


Name: KU-0060648
CAS#: 881375-00-4
Chemical Formula: C33H34N4O4S
Exact Mass: 582.23
Molecular Weight: 582.719
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Technical InformationSynonym: KU0060648; KU 0060648; KU-0060648.
Chemical Name: 4-Ethyl-N-[4-[2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-8-yl]-1-dibenzothienyl]-1-piperazineacetamide
InChi Key: AATCBLYHOUOCTO-UHFFFAOYSA-N
InChi Code: InChI=1S/C33H34N4O4S/c1-2-35-12-14-36(15-13-35)21-29(39)34-26-11-10-23(33-31(26)25-6-3-4-9-28(25)42-33)22-7-5-8-24-27(38)20-30(41-32(22)24)37-16-18-40-19-17-37/h3-11,20H,2,12-19,21H2,1H3,(H,34,39)
SMILES Code: O=C1C=C(N2CCOCC2)OC3=C(C4=C5C(C6=CC=CC=C6S5)=C(NC(CN7CCN(CC7)CC)=O)C=C4)C=CC=C13
实验参考方法

KU0060648 (KU-0060648) is a novel, potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK) with anticancer activity. It inhibits DNA-PK with an IC50 of 8.6 nM and exhibits 20-1000 fold selectivity for DNA-PK over other PIKKs and a panel of 60 kinases. KU-0060648 enhances HDR efficiency and attenuates NHEJ frequency. KU-0060648 is also considered as a dual inhibitor of DNA-PK and PI-3K. KU-0060648 inhibited cellular DNA-PK autophosphorylation with IC(50) values of 0.019 μmol/L (MCF7 cells) and 0.17 μmol/L (SW620 cells), and PI-3K-mediated AKT phosphorylation with IC(50) values of 0.039 μmol/L (MCF7 cells) and more than 10 μmol/L (SW620 cells). KU-0060648 inhibits hepatocellular carcinoma cells through DNA-PKcs-dependent and DNA-PKcs-independent mechanisms.

These protocols are for reference only. InvivoChem does not independently validate these methods.