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U-92016A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
U-92016A图片
CAS NO:149654-41-1
规格:98%
分子量:331.9
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
U-92016A is an agonist of the serotonin (5-HT) receptor subtype 5-HT1A (Ki = 0.4 nM).
CAS:149654-41-1
分子式:C19H25N3.HCl
分子量:331.9
纯度:98%
存储:Store at -20°C

Background:

U-92016A is an agonist of the serotonin (5-HT) receptor subtype 5-HT1A (Ki = 0.4 nM). It is selective for 5-HT1A over 5-HT1D, 5-HT2, dopamine D1 and D2, and α1- and α2-adrenergic receptors (Kis = 7.7, >1,000, >1,000, 36, >1,000, and >1,000 nM, respectively). U-92016A inhibits forskolin-stimulated cAMP synthesis in CHO cells transfected with human 5-HT1A. In vivo, U-92016A induces hypothermia in mice (ED50 = 0.041 mg/kg). It induces 5-HT syndrome, as measured by increased flat body posture and reciprocal forepaw treading, as well as decreases accumulation of 5-HT and dopamine in rats when administered at a dose of 5 mg/kg. U-92016A also decreases arterial blood pressure and heart rate in a dose-dependent manner in spontaneously hypertensive rats and reverses isolation-induced aggression in mice.