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Cyclic MKEY
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:934385-55-4
规格:98%
分子量:2532.89
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Cyclic MKEY 是 CXCL4-CCL5 异二聚体形成的合成环肽抑制剂,其通过介导炎症来防止动脉粥样硬化和主动脉瘤形成。Cyclic MKEY 还可以预防小鼠中风引起的脑损伤。
CAS:934385-55-4
分子式:C113H174N28O34S2
分子量:2532.89
纯度:98%
存储:Store at -20°C

Background:

Cyclic MKEY is a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, which protects against atherosclerosis and aortic aneurysm formation by mediating inflammation. Cyclic MKEY also protects against stroke-induced brain injury in mice[1][2]. CXCL4-CCL5 heterodimer formation[1]




[1]. Fan Y,et al. MKEY, a Peptide Inhibitor of CXCL4-CCL5 Heterodimer Formation, Protects Against Stroke in Mice. J Am Heart Assoc. 2016 Sep 15;5(9). pii: e003615. [2]. Iida Y, et al. Peptide inhibitor of CXCL4-CCL5 heterodimer formation, MKEY, inhibits experimental aortic aneurysm initiation and progression. Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):718-26.