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TH34
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TH34图片
CAS NO:2196203-96-8
规格:98%
分子量:256.305
包装与价格:
包装价格(元)
5mg电议
25mg电议

产品介绍

TH34

TH34 is a potent HDAC6/8/10 inhibitor
CAS:2196203-96-8
分子式:C15H16N2O2
分子量:256.305
纯度:98%
存储:Store at -20°C

Background:

TH34 is a potent HDAC6/8/10 inhibitor. TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines. The combination of TH34 with plasma-achievable concentrations of retinoic acid, a drug applied in neuroblastoma therapy, synergistically inhibits colony growth (combination index (CI) <?0.1 for 10 μM of each). In summary, our study supports using selective HDAC inhibitors as targeted antineoplastic agents and underlines the therapeutic potential of selective HDAC6/8/10 inhibition in high-grade neuroblastoma.


Reference


[1].Kolbinger FR, Koeneke E, Ridinger J, Heimburg T, Müller M, Bayer T, Sippl W,?Jung M, Gunkel N, Miller AK, Westermann F, Witt O, Oehme I. The HDAC6/8/10?inhibitor TH34 induces DNA damage-mediated cell death in human high-grade?neuroblastoma cell lines. Arch Toxicol. 2018 Aug;92(8):2649-2664. doi:?10.1007/s00204-018-2234-8. Epub 2018 Jun 9. PubMed PMID: 29947893; PubMed Central?
PMCID: PMC6063332.