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MJN110
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MJN110图片
CAS NO:1438416-21-7
规格:98%
分子量:462.3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
MAGL inhibitor
CAS:1438416-21-7
分子式:C22H21Cl2N3O4
分子量:462.3
纯度:98%
存储:Store at -20°C

Background:

Targets: MAGL


IC50: 9.1 nM


MJN110 is an N-hydroxysuccinimidyl carbamate with great, selective, and in-vivo-active inhibition effect for monoacylglycerol lipase (MAGL) with the IC50 value of 9.1 nM. Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) are biologically active lipids which participate in a mount of synaptic processes. MAGL is a serine hydrolase in charge of the hydrolysis of 2-AG to glycerol and arachidonic acid to terminate its function. And MJN110 could significantly inhibit the hydrolysis of 2-AG with the IC50 value of 2.1 nM without any effect on the hydrolysis of AEA up to 50 μM [1].


In Vitro: In HEK293T cells, MJN110 could inactivate hMAGL with the IC50 value of 9.1 nM, while having no effect on hFAAH activity. Besides, in human prostate cancer cell line PC3 cells which express both MAGL and ABDH6, MJN110 could selectively inhibit MAGL with the IC50 value of