CAS NO: | 337349-54-9 |
规格: | 98% |
分子量: | 383.5 |
包装 | 价格(元) |
5mg | 电议 |
25mg | 电议 |
Background:
Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand-induced and tumor necrosis factor-α (TNF-α) induced necrosis. Necrostatin-5 is a selective allosteric inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells with an EC50 value of 240 nM.