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Necrostatin-5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Necrostatin-5图片
CAS NO:337349-54-9
规格:98%
分子量:383.5
包装与价格:
包装价格(元)
5mg电议
25mg电议

产品介绍
Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis.
CAS:337349-54-9
分子式:C19H17N3O2S2
分子量:383.5
纯度:98%
存储:Store at -20°C

Background:

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand-induced and tumor necrosis factor-α (TNF-α) induced necrosis. Necrostatin-5 is a selective allosteric inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells with an EC50 value of 240 nM.