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Ribavirin 5'-monophosphate(lithium salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ribavirin 5'-monophosphate(lithium salt)图片
CAS NO:66983-94-6
规格:98%
分子量:336.1
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
Ribavirin 5'-monophosphate inhibits viral DNA and RNA replication in vitro via the strong competitive inhibition of inosine monophosphate dehydrogenase (IMPDH), with a reported Ki value of 270 nM, and thus inhibits guanosine triphosphate synthesis.
CAS:66983-94-6
分子式:C8H11N4O8P.2Li
分子量:336.1
纯度:98%
存储:Store at -20°C

Background:

Ribavirin 5'-monophosphate inhibits viral DNA and RNA replication in vitro via the strong competitive inhibition of inosine monophosphate dehydrogenase (IMPDH), with a reported Ki value of 270 nM, and thus inhibits guanosine triphosphate synthesis. This agent, a metabolite of the prodrug ribavirin , exhibits broad-spectrum antiviral activity, particularly against myxoviruses. The antiviral effects of ribavirin require conversion to the monophosphate form via adenosine kinase. The anti-HIV activity of ribavirin in cultured human lymphocytes, as well as the anti-influenza activity of this prodrug in MDCK cells, have been attributed to ribavirin 5'-monophosphate.