BI-11634 is a factor Xa inhibitor potentially for the treatment of cardiovascular disorders. The metabolism of BI-11634 in human liver microsomes was inhibited by ketoconazole and quinidine, well-accepted specific inhibitors of CYP3A4 and CYP2D6, respectively. In contrast, BI-11634 metabolism was exclusively mediated by rCYP3A4. Additional studies confirmed that BI-11634 was metabolized by CYP3A4 to form one major metabolite and this reaction was inhibited by quinidine. References: Mathur A, Tweedie DJ, Maw HH, Li Y. Unexpected interaction between CYP3A4 and BI 11634: is BI 11634 interacting with CYP3A4 similar to nifedipine? Drug Metabol Drug Interact. 2013;28(4):239-46. doi: 10.1515/dmdi-2013-0044. PubMed PMID: 24166670.

纯度：≥98%

CAS：1622159-00-5