CAS NO: | 615264-52-3 |
规格: | 98% |
分子量: | 325.4 |
包装 | 价格(元) |
500mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
Background:
Acyl-Coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis. CAY10486 inhibits human ACAT-1 and ACAT-2 equally with an IC50 value of approximately 60 µM. It also inhibits copper-mediated oxidation of low density lipoproteins by about 28% at a concentration of 3 µM.