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TPCA-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TPCA-1图片
CAS NO:507475-17-4
规格:98%
分子量:279.29
包装与价格:
包装价格(元)
5mg电议
10mg电议
100mg电议

产品介绍
IKK-2 inhibitor,potent and selective
CAS:507475-17-4
分子式:C12H10FN3O2S
分子量:279.29
纯度:98%
存储:Store at -20°C

Background:

TPCA-1 is a novel, potent, and selective inhibitor of human IKK-2.


Demonstration that IκB kinase 2 (IKK-2) plays a pivotal role in the nuclear factor-κB-regulated production of proinflammatory molecules by stimuli such as tumor necrosis factor (TNF)-α and interleukin (IL)-1 suggests that inhibition of IKK-2 may be beneficial in the treatment of rheumatoid arthritis.


In vitro: Determination of the activity of TPCA-1 against ten selected kinases, COX-1 and COX-2, showed the compound to be