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Risdiplam(RG7916)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Risdiplam(RG7916)图片
CAS NO:1825352-65-5
规格:98%
分子量:401.46
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Risdiplam(RG7916;RO7034067)是一种运动神经元存活基因SMN2的前体mRNA剪接修饰剂,可增加SMN蛋白水平。
CAS:1825352-65-5
分子式:C22H23N7O
分子量:401.46
纯度:98%
存储:Store at -20°C

Background:

Risdiplam (RG7916; RO7034067) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels.


Risdiplam modulates SMN2 pre-mRNA splicing towards the production of full-length SMN2 mRNA and increases SMN protein levels. Risdiplam is a modifier of SMN2 splicing, leading to an increase in SMN2 full length transcript and thus functional SMN protein. Spinal muscular atrophy (SMA) type I remains the most common genetic disease resulting in death in infancy. Characterized by progressive motor and respiratory muscle weakness, this autosomal recessive neuromuscular disorder is caused by low levels of the survival motor neuron protein (SMN) due to inactivating bi-allelic deletions and other disabling mutations in the survival motor neuron 1 (SMN1) gene[1].



[1]. Poirier A, et al. Risdiplam distributes and increases SMN protein in both the central nervous system and peripheral organs. Pharmacol Res Perspect. 2018 Nov 29;6(6):e00447.