BGG463 is a CDK2 inhibitor.
CAS：890129-26-7
分子式：C30H29F3N6O3
分子量：578.58
纯度：98%
存储：Store at -20°C
Background:
BGG463 (K03859) is an orally active type II CDK2 inhibitor[1].
BGG463 potently inhibits T315I BCR–ABL autophosphorylation and shows good oral efficacy in mouse models of CML[2].
参考文献:
[1]. Alexander LT, et al. Type II Inhibitors Targeting CDK2. ACS Chem Biol. 2015 Sep 18;10(9):2116-25.
[2]. Jones K, et al. Cancer Drug Discovery 2010: from molecules to medicine. Expert Rev Clin Pharmacol. 2010 Sep;3(5):613-5.
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