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4'-bromo-Resveratrol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
4'-bromo-Resveratrol图片
CAS NO:1224713-90-9
规格:98%
分子量:291.1
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Sirt1 and Sirt3 inhibitor
CAS:1224713-90-9
分子式:C14H11BrO2
分子量:291.1
纯度:98%
存储:Store at -20°C

Background:

4'-bromo-Resveratrol is a Sirt1 and Sirt3 inhibitor.


Sirtuins are protein deacetylases regulating aging processes and many physiological functions. Resveratrol activates human Sirt1 and inhibits Sirt3, and can mimic calorie restriction effects including lifespan extension in lower organisms.


In vitro: Sirtuin modulation was studied by using 4’-bromo-resveratrol in a previous study. 4’-bromo-Resveratrol inhibited Sirt3 with much higher potency than resveratrol, and it also inhibited rather than activated Sirt1. Crystal structures of human Sirt3/peptide complexes of 4’ -bromo-resveratrol identified two binding sites. An internal site caused the potent inhibitory effect. 4’-bromo-Resveratrol interfered with NAD+ and substrate peptide binding, and it extended its bromo-phenyl group in a unrecognized site pocket. The second binding site for 4’-bromo-resveratrol was found to be located on the surface of Sirt3 and connected via two helices to peptide-binding active site loops. In Sirt1, this site appeared to comprise a residue that was essential for its activation by small molecules and 4’-bromo-resveratrol therefore constituted a candidate for the long-sought allosteric Sirt1 activator binding site [1].


In vivo: So far, there is no animal in vivo data for 4'-bromo-resveratrol.


Clinical trial: Up to now, 4'-bromo-resveratrol is still in the preclinical development stage.


Reference:
[1] Nguyen GT, Gertz M, Steegborn C.  Crystal structures of Sirt3 complexes with 4'-bromo-resveratrol reveal binding sites and inhibition mechanism. Chem Biol. 2013 Nov 21;20(11):1375-85.