您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > WIKI4
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
WIKI4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
WIKI4图片
CAS NO:838818-26-1
规格:98%
分子量:521.59
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Inhibitor of Wnt/?-Catenin signaling and tankyrase
CAS:838818-26-1
分子式:C29H23N5O3S
分子量:521.59
纯度:98%
存储:Store at -20°C

Background:

WIKI4 is a potent tankyrase inhibitor with an IC50 of 26 nM for TNKS2. WIKI4 potently inhibits Wnt/β-catenin signaling and that its half-maximal response dose is 75 nM. WIKI4 mediates its effects on Wnt/β-catenin signaling by inhibiting the enzymatic activity of TNKS2[1][2]. WIKI4 is cytotoxic to SCLC cells with an IC50 value of 0.02 μM[3].


WIKI4 (100 nM, 1 μM; 6 days; DLD1 cells) inhibits growth of DLD1 cells relative to DMSO controls in media containing low serum. WIKI4 inhibits expression of β-catenin target genes and cellular responses to Wnt/β-catenin signaling[1].WIKI4 (1 μM; 2 hours, 4 hours, 6 hours, or 24 hours; DLD1 cells) significantly increases the steady-state abundance of AXIN1 and AXIN2[1].


参考文献:
[1]. James RG, et al. WIKI4, a novel inhibitor of tankyrase and Wnt/?-catenin signaling. PLoS One. 2012;7(12):e50457.
[2]. Haikarainen T, et al. Structural basis and selectivity of tankyrase inhibition by a Wnt signaling inhibitor WIKI4. PLoS One. 2013 Jun 6;8(6):e65404.
[3]. Sadava D, et al. The effect of brassinolide, a plant steroid hormone, on drug resistant small-cell lung carcinoma cells. Biochem Biophys Res Commun. 2017 Nov 4;493(1):783-787.