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Cysteamine(β-Mercaptoethylamine)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cysteamine(β-Mercaptoethylamine)图片
CAS NO:60-23-1
包装:5g
规格:98%
市场价:312元
分子量:77.15

产品介绍
Cysteamine为抗氧化剂,可作用于肾病型胱胺酸症。
CAS:60-23-1
分子式:C2H7NS
分子量:77.15
纯度:98%
存储:Store at -20°C

Background:

Cysteamine is an agent for the treatment of nephropathic cystinosis and an antioxidant.Target: OthersCysteamine has been shown to increase intracellular glutathione levels in cystinotic cells, thus restoring the altered redox state of the cells. Also increased rates of apoptosis in cystinotic cells, which are thought to be the result of increased caspase 3 and protein kinase Cε activity, is counteracted by Cysteamine administration. Cysteamine has antioxidant properties as a result of increasing glutathione production. Cysteamine is an excellent scavenger of OH and HOCl; it also reacts with H2O2. Cysteamine increases the production of several heat shock proteins (HSP), including the murine Hsp40. Cysteamine exerts a dose-dependent effect on the doxorubicin-induced death of cancer cells, measured in both HeLa cells and B16 cells, whereas Cysteamine treatment alone had no influence on cell survival. In addition, in a doxorubicin-resistant breast cancer cell line, the addition of Cysteamine to doxorubicin results in a dramatic increase in cell death [1]. Cysteamine (100 μM) significantly is able to increase the intracellular GSH levels and the percentage of embryos that developed to the blastocyst stage of culture matured oocytes [2].




[1]. de Matos, D.G., et al., Effect of cysteamine on glutathione level and developmental capacity of bovine oocyte matured in vitro. Mol Reprod Dev, 1995. 42(4): p. 432-6. [2]. Besouw, M., et al., Cysteamine: an old drug with new potential. Drug Discov Today, 2013. 18(15-16): p. 785-92.