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Miriplatin(SM-11355)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Miriplatin(SM-11355)图片
CAS NO:141977-79-9
规格:98%
分子量:764
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
Miriplatin为有效的化疗剂,是烷化剂(alkylator)的一种。
CAS:141977-79-9
分子式:C34H68N2O4Pt
分子量:764
纯度:98%
存储:Store at -20°C

Background:

Miriplatin is a chemotherapy agent which belongs to the class of alkylating agents.


Miriplatin suspended in LPD (miriplatin/LPD, 100 μg/mL) inhibits the growth of AH109A cells, forms platinum-DNA adducts, and induces apoptosis[2].


Miriplatin (0.02-0.4 mg/20 μL) in lipiodol reduces tumor growth rates in a dose dependent manner in rats bearing AH109A tumor cells[1]. Miriplatin/LPD (400 μg/head) significantly reduces the growth of tumor in rats bearing AH109A cells[2].


[1]. Kishimoto S, et al. Antitumor effects of a novel lipophilic platinum complex (SM-11355) against a slowly-growing rat hepatic tumor after intra-hepatic arterial administration. Biol Pharm Bull. 2000 Mar;23(3):344-8. [2]. Hanada M, et al. Intra-hepatic arterial administration with miriplatin suspended in an oily lymphographic agent inhibits the growth of tumors implanted in rat livers by inducing platinum-DNA adducts to form and massive apoptosis. Cancer Chemother Pharmacol. 2009 Aug;64(3):473-83.