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Irindalone(Lu 21-098)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Irindalone(Lu 21-098)图片
CAS NO:96478-43-2
规格:98%
分子量:408.51
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
20mg电议

产品介绍
Irindalone是一种5-羟色胺(5-HT2)拮抗剂。
CAS:96478-43-2
分子式:C24H29FN4O
分子量:408.51
纯度:98%
存储:Store at -20°C

Background:

Irindalone is a novel serotonin 5-HT2 antagonist.


Irindalone causes a concentration-related inhibition of serotonin-induced contractions and shifts the serotonin curve to the right. Irindalone is more potent in inhibiting the serotonin-induced contractions. Irindalone has a similar profile in vitro, with a high affinity for serotonin 5-HT2 receptors and about a 10 times lower affinity for α1-adrenoceptors[1].


Irindalone dose dependently lowers the blood pressure in spontaneously hypertensive rats (SHR) and renal hypertensive dogs[1].


[1]. Mikkelsen EO, et al. Comparison of the effect of irindalone, a novel serotonin 5-HT2 antagonist and ketanserin on mechanical responses of rat thoracic aorta. Eur J Pharmacol. 1988 Apr 27;149(1-2):145-8.