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Gly-Arg-Gly-Asp-Ser
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Gly-Arg-Gly-Asp-Ser图片
CAS NO:96426-21-0
规格:98%
分子量:490.47
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
25mg电议

产品介绍
Gly-Arg-Gly-Asp-Ser是一种五肽,构成了糖蛋白,骨桥蛋白与细胞的结合域。
CAS:96426-21-0
分子式:C17H30N8O9
分子量:490.47
纯度:98%
存储:Store at -20°C

Background:

Gly-Arg-Gly-Asp-Ser is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin.


Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3, with IC50 of 5 μM[1]. GRGDS-immobilized TiO2 nanotubes enhance osteoblast-like cell (MG-63) adhesion, and significantly increased cell spreading and proliferation[2].



[1]. Bernhagen D, et al. High-Affinity RGD-Knottin Peptide as a New Tool for Rapid Evaluation of the Binding Strength of Unlabeled RGD-Peptides to αvβ3, αvβ5, and α5β1 Integrin Receptors. Anal Chem. 2017 Jun 6;89(11):5991-5997. [2]. Kim GH, et al. Evaluation of Osteoblast-Like Cell Viability and Differentiation on the Gly-Arg-Gly-Asp-Ser Peptide Immobilized Titanium Dioxide Nanotube via Chemical Grafting. J Nanosci Nanotechnol. 2016 Feb;16(2):1396-9.