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KHK-IN-1 hydrochloride(ketohexokinase inhibitor
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
KHK-IN-1 hydrochloride(ketohexokinase inhibitor图片
CAS NO:1303470-48-5
规格:98%
分子量:459.01
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
KHK-IN-1盐酸盐是己酮糖激酶(KHK)高效抑制剂,IC50值12nM。
CAS:1303470-48-5
分子式:C21H27ClN8S
分子量:459.01
纯度:98%
存储:Store at -20°C

Background:

KHK-IN-1 Hcl is a potent ketohexokinase (KHK) inhibitor with IC50 of 12 nM, interacts with Asp-27B in the ATP-binding region of KHK.




[1]. Maryanoff BE, et al. Pyrimidinopyrimidine inhibitors of ketohexokinase: exploring the ring C2 group that interacts with Asp-27B in the ligand binding pocket. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5326-9. [2]. Maryanoff BE, et al. Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site. ACS Med Chem Lett. 2011 Apr 18;2(7):538-43.