CAS NO: | 1135688-47-9 |
规格: | 98% |
分子量: | 610.6 |
包装 | 价格(元) |
500ug | 电议 |
1mg | 电议 |
5mg | 电议 |
Background:
Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases.[1] At 10 µM, it can prevent the initiation of Fas signaling by caspase-10 in Jurkat T lymphoma cells, preventing Bid cleavage into its active form, caspase cascade activation, and apoptosis.[2]
Reference:
[1]. Park, S.J., Wu, C.H., Gordon, J.D., et al. Taxol induces caspase-10-dependent apoptosis. The Journal of Biological Chemisty 279(49), 51057-51067 (2004).
[2]. Milhas, D., Cuvillier, O., Therville, N., et al. Caspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosis. The Journal of Biological Chemisty 280(20), 19836-19842 (2005).