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Thioperamide(maleate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Thioperamide(maleate)图片
CAS NO:148440-81-7
规格:98%
分子量:408.5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
Thioperamide (maleate) is a selective histamine H3 receptor antagonist that crosses the blood-brain barrier.
CAS:148440-81-7
分子式:C15H24N4S.C4H4O4
分子量:408.5
纯度:98%
存储:Store at -20°C

Background:

Thioperamide (maleate) is a selective histamine H3 receptor antagonist that crosses the blood-brain barrier. This compound binds to rat cerebral cortical cells in vitro with a pKi value of 8.4 and inhibits histamine binding in vivo with an ED50 value of 1 mg/kg.[1] At a dose of 5 mg/kg thioperamide (maleate) inhibits kindled seizures in rats by decreasing histamine and gamma-aminobutyric acid.[2]


Reference:
[1]. Meir, G., Apelt, J., Reichert, U., et al. Influence of imidazole replacement in different structural classes of histamine H3-receptor antagonists. European Journal of Pharmaceutical Sciences 13, 249-259 (2001).
[2]. Harada, C., Fujii, Y., Hirai, T., et al. Inhibitory effect of iodophenprofit, a selective histamine H3 antagonist, on amygdaloid kindled seizures. Brain Research Bulletin 63, 143-146 (2004).