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BI-6C9
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BI-6C9图片
CAS NO:791835-21-7
规格:98%
分子量:471.6
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
BH3-interacting domain (Bid) is cleaved by caspase-8 to produce the truncated protein tBid, which facilitates cytochrome c release from mitochondria and drives apoptosis.
CAS:791835-21-7
分子式:C23H25N3O4S2
分子量:471.6
纯度:98%
存储:Store at -20°C

Background:

BH3-interacting domain (Bid) is cleaved by caspase-8 to produce the truncated protein tBid, which facilitates cytochrome c release from mitochondria and drives apoptosis. BI-6C9 is an inhibitor of tBid (Kd = 20 µM), blocking the release of both cytochrome c and second mitochondria-derived activator of caspase from mitochondria. It prevents apoptosis in neurons treated with glutamate or oxygen-glucose deprivation. BI-6C9 (10 µM) also inhibits the nuclear translocation of apoptosis-inducing factor AIF, preventing the death of ovarian OVCAR-3 cancer cells induced by IFN-α2a.