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D-erythro-MAPP
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
D-erythro-MAPP图片
CAS NO:143492-38-0
规格:98%
分子量:361.6
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议
10mg电议

产品介绍
D-erythro-MAPP is a derivative of ceramide and an inhibitor of alkaline ceramidase (Ki = 2-13 μM; IC50 = 1-5 μM).
CAS:143492-38-0
分子式:C23H39NO2
分子量:361.6
纯度:98%
存储:Store at -20°C

Background:

D-erythro-MAPP is a derivative of ceramide and an inhibitor of alkaline ceramidase (Ki = 2-13 µM; IC50 = 1-5 µM). It is selective for alkaline ceramidase over acid ceramidase (IC50 = >500 µM) as well as the serine/threonine protein phosphatase CAPP at concentrations up to 10 µM. D-erythro-MAPP increases intracellular ceramide levels, induces cell cycle arrest at the G0/G1 phase, and inhibits growth of HL-60 promyelocytic leukemia cells in a time- and concentration-dependent manner.