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Voacangine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Voacangine图片
CAS NO:510-22-5
规格:98%
分子量:368.5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Voacangine is an indole alkaloid that has been found in T.
CAS:510-22-5
分子式:C22H28N2O3
分子量:368.5
纯度:98%
存储:Store at -20°C

Background:

Voacangine is an indole alkaloid that has been found in T. citrifolia, V. africana, V. obtusa, and T. iboga with diverse biological activities. It inhibits the growth of M. tuberculosis, M. avium, and M. kansasii with MIC values of 50, >200, and 100 μg/mL, respectively. Voacangine (0.01-100 μM) dose-dependently reduces membrane currents in HEK293 cells expressing the hERG potassium channel and displaces the hERG ligand dofetilide with a Ki value of 3.9 μM. Voacangine suppresses agonist-induced activation of transient receptor potential (TRP) channels with IC50 values of 50 and 9 μM for activation induced by the TRPV1 agonist capsaicin and the TRPM8 agonist menthol, respectively. It also activates TRPA1 channels and stimulates calcium influx (IC50 = 8 μM in HEK293 cells expressing TRPA1), an effect that is blocked by the TRPA1 blocker HC-030031 . In vivo, voacangine (2 and 4 μg per egg) inhibits angiogenesis in chick embryo chorioallantoic membranes without apparent cytotoxicity.