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YLF-466D
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
YLF-466D图片
CAS NO:1273323-67-3
规格:98%
分子量:465.9
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
YLF-466D is an orally bioavailable activator of AMP-activated protein kinase (AMPK), an enzyme involved in regulation of cellular energy homeostasis.
CAS:1273323-67-3
分子式:C29H20ClNO3
分子量:465.9
纯度:98%
存储:Store at -20°C

Background:

YLF-466D is a newly developed AMPK activator, which inhibits platelet aggregation.


The effect of YLF-466D on platelet AMPK and aggregation are examined to test whether YLF-466D can stimulate AMPK in platelets and thereby suppress aggregation. Platelet AMPK is activated by YLF-466D, which is confirmed with activation-dependent phosphorylation at Thr172. Consistent with this result, YLF-466D inhibits platelet aggregation induced by thrombin. Such inhibition is observed in the aggregation elicited by ADP and collagen as well as thrombin, indicating that the antiaggregatory effect of YLF-466D is not platelet-agonist specific but common, regardless of agonist type. All the effects on AMPK and aggregation are concentration-dependent with the highest efficacy at 150 μM. IC50 against thrombin-, ADP- and collagen-induced aggreation are approximately 84, 55 and 87 μM, respectively[1].


参考文献:
[1]. Liu Y, et al. Antiplatelet effect of a newly developed AMP-activated protein kinase activator YLF-466D. Eur J Pharmacol. 2015 Aug 5;760:81-7.