JWH 412 is a positional isomer of AM2201 that was identified in the ‘herbal mixture'-XoXo.
CAS：1364933-59-4
分子式：C24H22FNO
分子量：359.4
纯度：98%
存储：Store at -20°C

Background:

JWH 412 is a positional isomer of AM2201 that was identified in the ‘herbal mixture’ XoXo.1 The substitution of hydrogen against fluorine in the 4-position of the naphthyl moiety enhances the binding affinity to the central cannabinoid (CB1) receptor compared to the unsubstituted JWH 018.[1] JWH 412 demonstrates Ki values of 7.2 and 3.2 nM at CB1 and peripheral CB2 receptors, respectively.[2] This product is intended for research and forensic purposes.

Reference:
[1]. Moosmann, B., Kneisel, S., Girreser, U., et al. Separation and structural characterization of the synthetic cannabinoids JWH-412 and 1-[(5-fluoropentyl)-1H-indol-3yl]-(4-methylnaphthalen-1-yl)methanone using GC-MS, NMR analysis and a flash chromatography system. Forensic Science International 220(1-3), e17-e22 (2012).
[2]. Smith, V.J. Synthesis and pharmacology of N-alkyl-3-(halonaphthoyl)indoles. Doctor of Philosophy Chemistry, 1-179-179 (2008).