Chk2 inhibitor,potent and highly selective
CAS：516480-79-8
分子式：C20H14ClN3O2
分子量：363.8
纯度：98%
存储：Store at -20°C

Background:

BML-277 is novel, potent and highly selective inhibitor of the chk2 with the IC50 value of 15±6.9nM [1].

BML-277 has shown the ATP-competitive inhibition of chk2 with the Ki value of 37nM. BML-277 has also been exhibited to be a chk2 inhibitor with the IC50 value of 15±6.9nM and efficiently rescue T-cell populations from the apoptosis of radiation-induced in a concentration-dependent fashion with the EC50 of 3