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Nexturastat A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nexturastat A图片
CAS NO:1403783-31-2
规格:98%
分子量:341.4
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
HDAC6 inhibitor,highly potent and selective
CAS:1403783-31-2
分子式:C19 H23 N3 O3
分子量:341.4
纯度:98%
存储:Store at -20°C

Background:

Nexturastat A is a selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 value of 5.2 nM [1].


Nexturastat A is a HDAC inhibitor. It was developed by structural modification of aryl urea HDACIs. The inhibitory activity of Nexturastat A is most potent against HDAC6 with IC50 value of 5.2 nM. Besides that, Nexturastat A also shows inhibition of other HDACs with IC50 values of 3.02, 6.92, 6.68, 9.39, 11.7, 4.46, 0.954, 6.72, 7.57 and 5.14 μM for HDAC1, 2, 3, 4, 5, 7, 8, 9, 10 and 11, respectively. Nexturastat A has been shown to suppress cell proliferation and promote apoptosis in B16 murine melanoma cells [1, 2].


参考文献:
[1] Kalin J H, Bergman J A. Development and therapeutic implications of selective histone deacetylase 6 inhibitors. Journal of medicinal chemistry, 2013, 56(16): 6297-6313.
[2] Zhang L, Han Y, Jiang Q, et al. Trend of Histone Deacetylase Inhibitors in Cancer Therapy: Isoform Selectivity or Multitargeted Strategy. Medicinal research reviews, 2014.