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Genistin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Genistin图片
CAS NO:529-59-9
包装:20mg
规格:98%
市场价:1389元
分子量:432.37

产品介绍
TdT inhibitor
CAS:529-59-9
分子式:C21H20O10
分子量:432.37
纯度:98%
存储:Store at -20°C

Background:

Genistin is the major isoflavonoid of soybeans and soy products.


Genistin is the major isoflavonoid of soybeans and soy products. Genistin shows a dose-dependent superoxide scavenging effect and exhibits major effect at 200 μM, corresponding in activity to 0.08 U/mg protein superoxide dismutase (SOD). Results demonstrate that Genistin exhibits a significantly (P<0.01) and a dose-dependent inhibitory effect on the human cancer cell examined, and at higher concentration (100 μM), the cell viability is 59%. Genistin also induces a significant and dose-dependent increase in ROS formation when compare with the untreated control[1].


Myocardial infarct is markedly diminished by pretreatment with Genistin, particularly at the high dose. After 1?h of reperfusion, preconditioning with Genistin at dosages of 20 to 60?mg/kg significantly attenuats the release of lactate dehydrogenase (LDH), creatine kinase (CK) in a dose-dependent manner compare with the I/R group. Results show that the level of malondialdehyde (MDA) is decreased and the activities of superoxide dismutase (SOD) and catalase (CAT) are increased as well as an increased glutathione (GSH) level in a dose-dependent manner by Genistin treatment in I/R. Pretreatment with Genistin (20, 40 and 60?mg/kg) also prevents the expression of P2X7, p-IκBα, and p-NF-κB p65 compare with the model group[2].


参考文献:
[1]. Russo A, et al. Genistin inhibits UV light-induced plasmid DNA damage and cell growth in human melanoma cells. J Nutr Biochem. 2006 Feb;17(2):103-8.
[2]. Gu M, et al. Cardioprotective Effects of Genistin in Rat Myocardial Ischemia-Reperfusion Injury Studies by Regulation of P2X7/NF-κB Pathway. Evid Based Complement Alternat Med. 2016;2016:5381290.