NIC3 是一种选择性的伏隔核相关蛋白 1 (NAC1) 抑制剂，与 NAC1 的保守位点 Leu-90 结合，阻止其同源二聚化，导致蛋白酶体 NAC1 的降解。具有抗肿瘤活性。
CAS：494830-67-0
分子式：C26H36N2O4
分子量：440.58
纯度：98%
存储：Store at -20°C

Background:

NIC3 is a selective nucleus accumbens-associated protein-1 (NAC1) inhibitor, binds to the conserved Leu-90 of NAC1, prevents its homodimerization, and leads to proteasomal NAC1 degradation. Anti-cancer activity[1]. NAC1[1]

[1]. Wang X, et al. Identification of a small-molecule compound that inhibits homodimerization of oncogenic NAC1 protein and sensitizes cancer cells to anticancer agents. J Biol Chem. 2019 May 17. pii: jbc.RA119.007664.