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Ivachtin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ivachtin图片
CAS NO:745046-84-8
规格:98%
分子量:447.46
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Caspase-3 inhibitor
CAS:745046-84-8
分子式:C20H21N3O7S
分子量:447.46
纯度:98%
存储:Store at -20°C

Background:

Ivachtin is a potent inhibitor of caspase-3 with IC50 value of 23 nM [1].


Caspase-3 is a member of the cysteine-aspartic acid protease family and interacts with caspase-8 and caspase-9. Sequential activation of caspases plays an important role in cell apoptosis.


Ivachtin is a potent and reversible inhibitor of caspase-3 in a noncompetitive way. Ivachtin was the most potent inhibitor against caspase-3, but the selectivity versus the remaining caspases was modest. In human Jurkat T cells treated with 10 μM staurosporin, Ivachtin protected cells in a higher level, which suggested that Ivachtin had a good cell permeability and antiapoptotic activity [1].


Reference:
[1]. Kravchenko DV, Kuzovkova YA, Kysil VM, et al. Synthesis and structure-activity relationship of 4-substituted 2-(2-acetyloxyethyl)-8-(morpholine-4-sulfonyl)pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors. J Med Chem, 2005, 48(11): 3680-3683.