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8,11,14-Eicosatriynoic Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
8,11,14-Eicosatriynoic Acid图片
CAS NO:34262-64-1
规格:98%
分子量:300.4
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
A Cox, 12-LO, and 5-LO inhibitor
CAS:34262-64-1
分子式:C20H28O2
分子量:300.4
纯度:98%
存储:Store at -20°C

Background:

8,11,14-Eicosatriynoic Acid, as an inhibitor of prostaglandin, leukotriene biosynthesis, and arachidonic acid induced platelet aggregation, blocks human 12-lipoxygenase (12-LO), cyclooxygenase (COX), and 5-lipoxygenase (5-LO) with IC50 values of 0.46 μM, 14 μM, and 25 μM, respectively. Also, it inhibits the actions of slow-reacting substance of anaphylaxis with an IC50 value of 10 μM [1,2].


Lipoxygenases are found widely in fungi, plants, and animals in high levels. 12-LO is involved in a number of significant disease states and may play a role in oxidative glutamate toxicity. COX enzymes play elaborate roles in human physiology and pathology, involving neuronal, immune, renal, cardiovascular, gastrointestinal, and reproductive systems. COX enzymes are blocked by aspirin and a wide variety of other non-steroidal anti-inflammatory drugs, which makes them important clinically [3]. 5-LO is involved in cancer pathobiology. It is expressed by a variety of cancer cells including colon, lung, breast, and prostate and promotes cancer cell growth and neo-angiogenesis.


In vitro: Up to now, in vitro study of 8,11,14-Eicosatriynoic Acid is still in the development stage.


In vivo: Up to now, in vivo study of 8,11,14-Eicosatriynoic Acid is still in the development stage.


参考文献:
[1].  Goetz, J., Sprecher, H., Cornwell, D., & Panganamala, R. Inhibition of prostaglandin biosynthesis by triynoic acids. Prostaglandins. 1976; 12(2): 187-192.
[2].  Sun, F., McGuire, J., Morton, D., Pike, J., Sprecher, H., & Kunau, W. Inhibition of platelet arachidonic acid 12-lipoxygenase by acetylenic acid compounds. Prostaglandins. 1981; 21(2): 333-343.
[3].  Fitzpatrick, F. Cyclooxygenase Enzymes: Regulation and Function. Current Pharmaceutical Design. 2004; 10(6): 577-588.