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Naspm(1-Naphthylacetyl spermine)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Naspm(1-Naphthylacetyl spermine)图片
CAS NO:122306-11-0
规格:98%
分子量:370.53
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
Naspm(1-Naphthylacetylspermine)是Joro蜘蛛毒素的合成类似物,是CP-AMPA受体拮抗剂。
CAS:122306-11-0
分子式:C22H34N4O
分子量:370.53
纯度:98%
存储:Store at -20°C

Background:

Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.


NASPM selectively suppresses the inwardly rectifying and Ca2+-permeable AMPA receptors expressed in type II neurons. It has no effect on AMPA receptors in type I neurons. At -60 mV, NASPM suppresses AMPA receptors in type II neurons with an IC50 value of 0.33 µM. The blocking effect of NASPM on the Ca2+-permeable AMPA receptors is use and voltage-dependent[1].



[1]. Koike M, et al. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci Res. 1997 Sep;29(1):27-36.