E3 ligase Ligand 16 是一种 E3 泛素连接酶配体。E3 ligase Ligand 16 可以通过 linker 与靶蛋白配体连接，形成 PROTAC 或 SNIPER。PROTAC 可诱导促癌蛋白发生泛素化降解。
CAS：2249750-27-2
分子式：C32H32Cl2N4O6
分子量：639.53
纯度：98%
存储：Store at -20°C

Background:

E3 ligase Ligand 16 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 16 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].

[1]. Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575.