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2',3'-Dideoxyadenosine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
2',3'-Dideoxyadenosine图片
CAS NO:4097-22-7
包装:10mg
规格:98%
市场价:712元
分子量:235.24

产品介绍
2',3'-Dideoxyadenosine是HIV复制抑制剂。抗逆转录病毒活性。抗病毒活性[1]。
CAS:4097-22-7
分子式:C10H13N5O2
分子量:235.24
纯度:98%
存储:Store at -20°C

Background:

2’,3’-Dideoxyadenosine is an inhibitor of HIV replication[1]. Antiretroviral activity[1]. Antiviral efficacy[1].


2’,3’-Dideoxyadenosine inhibits HIV-1 and simian immunodeficiency virus (SIV) in MT-4 cells with EC50s of 5.27 and 5.3 μM, respectively. 2’,3’-Dideoxyadenosine inhibits HIV-1 and HIV-2 in human T-lymphocyte CEM cells with EC50s of 4 μM and 8 μM, respectively. 2’,3’-Dideoxyadenosine inhibits HIV-1 and HIV-2 in Molt 4/C8 cells with EC50s of 4 μM and 5.5 μM, respectively. 2’,3’-Dideoxyadenosine inhibits HIV-1 and HIV-2 in C8166 cells with EC50s of 17 μM and 22 μM, respectively. 2’,3’-Dideoxyadenosine inhibits murine sarcoma virus (MSV) in C3H/3T3 cells with an EC50 of 24 μM[1].



[1]. Balzarini J, et al. Conversion of 2’,3’-dideoxyadenosine (ddA) and 2’,3’-didehydro-2’,3’-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus. FEBS Lett. 1997 Jun 30;410(2-3):324-8.