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L-755,507
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
L-755,507图片
CAS NO:159182-43-1
规格:98%
分子量:584.73
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
β3 adrenergic receptor agonist
CAS:159182-43-1
分子式:C30H40N4O6S
分子量:584.73
纯度:98%
存储:Store at -20°C

Background:

IC50: 13 nM (binding at the human β3 adrenergic receptor) [1]


Benzenesulfonamide derivative L-755,507 is a partial agonist for the human β3 receptor, with maximal activation 52% of that evoked by isoproterenol [2]. β3 adrenergic receptor is a G protein-coupled receptors which can enhancement of lipolysis in adipose tissue.


In vitro: L-755,507 displays an excellent activity profile as an extremely potent human β3 adrenergic receptor agonist (β3 EC50 0.43 nM), with >440-fold selectivity over β1 and β2 binding [1]. L-755,507 is also a potent and selective b3 partial agonist in rhesus monkeys as assessed by its affinity for the cloned b adrenergic receptors, and stimulates lipolysis in rhesus adipocytes with an EC50 = 3.9 nM [2].


In vivo: Dose rhesus monkeys with L-755,507 elicits lipolysis and metabolic rate elevation. The ED50 for glycerolemia was 0.03 mg/kg and the ED50 for tachycardia was 2.5 mg/kg, and stimulates metabolic rate by