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Wortmannin-Rapamycin Conjugate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Wortmannin-Rapamycin Conjugate图片
CAS NO:1067892-47-0
规格:98%
分子量:1598.9
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
Phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) act synergistically in promoting cancer.
CAS:1067892-47-0
分子式:C88H131N3O23
分子量:1598.9
纯度:98%
存储:Store at -20°C

Background:

Phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) act synergistically in promoting cancer. Wortmannin is a potent inhibitor of PI3K enzymes, while rapamycin blocks mTOR Complex 1 TORC1. Wortmannin-rapamycin conjugate consists of analogs of 17-hydroxy wortmannin and rapamycin conjugated via a prodrug linker. Hydrolysis of the prodrug linker in vivo releases the inhibitors. The wortmannin-rapamycin conjugate inhibits the growth of HT-29 colon tumors and A498 renal tumors in mice better than rapamycin alone. Also, the conjugate, when given in combination with the VEGF-blocker bevacizumab, produces substantial regression of larger A498 tumors. Finally, the wortmannin-rapamycin conjugate is tolerated better than an equivalent mixture of the inhibitors.