您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > D-Amino Acid Oxidase Inhibitor
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
D-Amino Acid Oxidase Inhibitor
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
D-Amino Acid Oxidase Inhibitor图片
CAS NO:39793-31-2
规格:98%
分子量:167.2
包装与价格:
包装价格(元)
250mg电议
500mg电议
1g电议
5g电议

产品介绍
D-Amino acid oxidase inhibitor is an inhibitor of D-amino acid oxidase (DAAO) with IC50 values of 145 and 114 nM in CHO cells expressing human and rat DAAO, respectively.
CAS:39793-31-2
分子式:C7H5NO2S
分子量:167.2
纯度:98%
存储:Store at -20°C

Background:

D-Amino acid oxidase inhibitor is an inhibitor of D-amino acid oxidase (DAAO) with IC50 values of 145 and 114 nM in CHO cells expressing human and rat DAAO, respectively. It is selective for DAAO over a panel of 150 enzymes, receptors, and ion channels when used at a concentration of 30 μM. D-Amino acid oxidase inhibitor (10-200 mg/kg, i.p.) inhibits DAAO activity in rat kidney and cerebellum in a dose- and time-dependent manner. It increases levels of D-serine in rat plasma and cerebral spinal fluid (CSF) but has no effect on hyperlocomotion or dopamine efflux in the nucleus accumbens induced by amphetamine in rats. DAAO inhibitor reduces formalin-induced paw flinching in rats (EC50 = 0.17 μg per animal) indicating an antinociceptive effect.