Quinine is an alkaloid antimalarial agent that has MIC values ranging from 10 to 500 nM for 60 Thai isolates of P.
CAS：130-95-0
分子式：C20H24N2O2
分子量：324.4
纯度：98%
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Background:

Quinine is an alkaloid antimalarial agent that has MIC values ranging from 10 to 500 nM for 60 Thai isolates of P. falciparum.¹It inhibits hemozoin formation in purified trophozoites, leading to an increase in free heme, similar to the mechanism of action of chloroquine .²In mice, quinine reduces P. berghei parasite load in the blood with a minimum effective dose (MED) of 150 mg/kg.³Formulations containing quinine have been used in the treatment of uncomplicated malaria.

参考文献：

1. Thaithong, S., Beale, G.H., and Chutmongkonkul, M. Susceptibility of Plasmodium falciparum to five drugs: An in vitro study of isolates mainly from Thailand. Trans. R. Soc. Trop. Med. Hyg. 77(2), 228-231 (1983).

2. Combrinck, J.M., Mabotha, T.E., Ncokazi, K.K., et al. Insights into the role of heme in the mechanism of action of antimalarials. ACS Chem Biol. 8(1), 133-137 (2013).

3. Thurston, J.P. The action of antimalarial drugs in mice infected with Plasmodium berghei. Br. J. Pharmacol. Chemother. 5(3), 409-416 (1950).