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S14161
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
S14161图片
CAS NO:883046-50-2
规格:98%
分子量:315.3
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
D-Cyclins regulate the cell cycle by acting in a complex with cyclin dependent kinases (CDKs) to promote phosphorylation of the retinoblastoma protein and initiate cellular progression from the G1 to the S phase.
CAS:883046-50-2
分子式:C17H14FNO4
分子量:315.3
纯度:98%
存储:Store at -20°C

Background:

D-Cyclins regulate the cell cycle by acting in a complex with cyclin dependent kinases (CDKs) to promote phosphorylation of the retinoblastoma protein and initiate cellular progression from the G1 to the S phase. Cell cycle deregulation in many cancers often results from altered cyclin D/CDK activity. S14161 is a small molecule inhibitor of cyclins D1-D3 expression that inhibits phosphoinositide 3-kinase activity and arrests cells at the G0/G1 phase in a dose-dependent manner (concentrations tested from 5-10 μM). S14161 induces apoptosis in myeloma and leukemia cell lines (IC50s 25 μM). In a mouse model of leukemia, S14161 delayed tumor growth by up to 90% compared to controls at a dose of 100 mg/kg/day.