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α-Hydroxyglutaric Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
α-Hydroxyglutaric Acid图片
CAS NO:2889-31-8
规格:98%
分子量:148.1
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
α-Hydroxyglutaric acid (2-HG) is an α-hydroxy acid.
CAS:2889-31-8
分子式:C5H8O5
分子量:148.1
纯度:98%
存储:Store at -20°C

Background:

α-Hydroxyglutaric acid (2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases, and mutations in these enzymes lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased levels of L-2-hydroxyglutaric acid . 2-HG can also be metabolized from isocitrate by mutated forms of isocitrate dehydrogenase 1 (IDH1) and IDH2. 2-HG is structurally similar to α-ketoglutarate, the product of wild-type isocitrate dehydrogenases, and competitively inhibits α-ketoglutarate-dependent dioxygenases, including histone lysine demethylases and DNA hydroxylases.