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PF-04929113(SNX-5422)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PF-04929113(SNX-5422)图片
CAS NO:908115-27-5
规格:98%
分子量:521.5
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
Hsp90 inhibitor,potent and selective
CAS:908115-27-5
分子式:C25H30F3N5O4
分子量:521.5
纯度:98%
存储:Store at -20°C

Background:

PF-04929113 is an inhibitor of Hsp90 [1].


PF-04929113 is a water-soluble and oral pre-PF-04928473, which can be rapidly absorbed and converted into PF-04928473 after oral administration. In BT-474 xenograft mice, PF-04928473 induced the degradation of HER2 client protein. No obvious toxicity was observed when the dose reached 150mg/kg. PF-04928473 at 100mg/kg resulted in complete tumor growth inhibition and local tumor regression in some mice. In H1650 xenograft mice, PF-04928473 also showed significant anti-tumor activity. In addition, as an inhibitor of Hsp90, PF-04928473 inhibits p-ERK and p-Akt in vivo, reduces CD31+ cells and MVD, and has an effect on angiogenesis [1,2].


参考文献:
[1] Chandarlapaty S, Sawai A, Ye Q, Scott A, Silinski M, Huang K, Fadden P, Partdrige J, Hall S, Steed P, Norton L, Rosen N, Solit DB. SNX2112, a synthetic heat shock protein 90 inhibitor, has potent antitumor activity against HER kinase-dependent cancers. Clin Cancer Res. 2008 Jan 1;14(1):240-8.
[2] Okawa Y, Hideshima T, Steed P, Vallet S, Hall S, Huang K, Rice J, Barabasz A, Foley B, Ikeda H, Raje N, Kiziltepe T, Yasui H, Enatsu S, Anderson KC. SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK. Blood. 2009 Jan 22;113(4):846-55.