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α-Amyloid Precursor Protein Modulator
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
α-Amyloid Precursor Protein Modulator图片
CAS NO:497259-23-1
包装:1mg
规格:98%
市场价:1540元
分子量:501.54

产品介绍
PKC activator
CAS:497259-23-1
分子式:C27H30F3N3O3
分子量:501.54
纯度:98%
存储:Store at -20°C

Background:

α-Amyloid Precursor Protein Modulator is a benzolactam derived PKC activator.


Protein kinase C (PKC) belongs to a family of protein kinase enzymes involved in phosphorylating serine and threonine of other proteins. The PKC enzymes have been involved in regulating the function of other proteins. Protein kinase C plays an important role in several signal transduction cascades. Protein kinase C has been involved in modulating membrane structure events, mediating immune responses, regulating transcription, learning and memory, and regulating cell growth [2].


α-Amyloid Precursor Protein Modulator activated PKC with the Ki value of 11.9 nM for PKCα that efficiently enhanced non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848. α-Amyloid Precursor Protein Modulator displayed a marked loss of tumor promoting activity [1].


参考文献:
[1] Kozikowski A P, Nowak I, Petukhov P A, et al.  New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPα[J]. Journal of medicinal chemistry, 2003, 46(3): 364-373.
[2] Stabel S, Parker P J.  Protein kinase C[J]. Pharmacology & therapeutics, 1991, 51(1): 71-95.