您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Caspofungin Acetate
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Caspofungin Acetate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Caspofungin Acetate图片
CAS NO:179463-17-3
规格:98%
分子量:1213.42
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍

lipopeptide antifungal drug
CAS:179463-17-3
分子式:C56H96N10O19
分子量:1213.42
纯度:98%
存储:Store at -20°C

Background:

Caspofungin acetate(MK-0991), a new antifungal agent with minimal toxicity, inhibits synthesis of 1,3-β-D-glucan, an essential component of the fungal cell wall [1].

In vitro: Incubation ofA. fumigatuwith a single dose of caspofungin affected the same proportion of apical and subapical branching cells for up to 72 h.The cells at the active centers for new cell wall synthesis withinA. fumigateshyphae are killed when they are exposed to caspofungin [1]. Caspofungin acetate irreversibly inhibited the enzyme 1,3-β-D-glucan synthase, preventing the formation of glucan polymers and disrupting the integrity of the fungal cell wall. The elimination half-life of caspofungin acetate was 9-10 hours [2]. Caspofungin showed activity againstAspergillusspp. as well as a variety ofCandidaspp[3]. Growth kinetic studies of caspofungin acetate against Candida albicans and Candida tropicalis isolates showed that caspofungin acetate exhibited fungicidal activity (i.e., a 99% reduction in viability) within 3 to 7 h at concentrations ranging from 0.06 to 1 μg/ml (0.25 to 4 times the MIC)[4].The minimal inhibitory concentration for 90% inhibition of Candida species by caspofungin acetate were as follows:C. albicans 0.5 μg/mL (range, 0.25-0.5), C. glabrata 1.0 μg/mL (range, 0.25-2.0), C. tropicalis 1.0 μg/mL (range, 0.25-1.0), C. parapsilosis 0.5 μg/mL (range, 0.25-1.0), and C. krusei 2.0 μg/mL (range, 0.5-2.0)[4].

Clinical trials: In a trial of 128 patients with Candida esophagitis, clinical response rates were higher with caspofungin acetate 50 or 70 mg/day (85%) than with amphotericin B 0.5 mg/kg/day (67%)[2].

参考文献:
[1]. Bowman J C, Hicks P S, Kurtz M B, et al. The antifungal echinocandincaspofungin acetate kills growing cells of Aspergillus fumigatus in vitro[J]. Antimicrobial agents and chemotherapy, 2002, 46(9): 3001-3012.
[2]. Hoang A. Caspofungin acetate: an antifungal agent[J]. American journal of health-system pharmacy, 2001, 58(13): 1206-1214.
[3]. Pacetti S A, Gelone S P. Caspofungin acetate for treatment of invasive fungal infections[J]. Annals of Pharmacotherapy, 2003, 37(1): 90-98.
[4]. Bartizal K, Gill C J, Abruzzo G K, et al. In vitro preclinical evaluation studies with the echinocandin antifungal MK-0991 (L-743,872)[J]. Antimicrobial Agents and Chemotherapy, 1997, 41(11): 2326-2332.