Auristatin E是细胞毒性分子，微管蛋白修饰分子，强效抗肿瘤活性，MMAE的类似物以及在抗体药物偶连体开发中作为毒素分子。
CAS：160800-57-7
分子式：C40H69N5O7
分子量：732.01
纯度：98%
存储：Store at -20°C

Background:

Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAE analog and cytotoxin in Antibody-drug conjugates.

[1]. Francisco JA, et al. cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity. Blood. 2003 Aug 15;102(4):1458-65. [2]. Li D, et al. DCDT2980S, an anti-CD22-monomethyl auristatin E antibody-drug conjugate, is a potential treatment for non-Hodgkin lymphoma. Mol Cancer Ther. 2013 Jul;12(7):1255-65.