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Benzalkonium chloride(Alkyldimethylbenzylammonium chloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Benzalkonium chloride(Alkyldimethylbenzylammonium chloride)图片
CAS NO:8001-54-5
包装:1g
规格:98%
市场价:445元

产品介绍
Benzalkoniumchloride是一种有效的抗菌剂,在滴眼液中用作防腐剂。
CAS:8001-54-5
分子式:C6H5CH2N(CH3)2RCl (R=C8H17 to C18H37)
分子量:
纯度:98%
存储:Store at -20°C

Background:

Benzalkonium chloride is a potent anti-microbial agent, used as a preservative in eye drops.


Benzalkonium chloride (0.0001%-0.5%) results in a dose-dependent cytotoxicity in cells. Benzalkonium chloride also shows cytotoxicity against human keratinocytes, with 50% loss of viability of 4 μM. Benzalkonium chloride shows different results in NHEK and NB1RGB cell cultures, and the ED50 of 3.9 and 62 μM, respectively. The clinically used concentration (0.01% Benzalkonium chloride) significantly reduces cell viability, with only 14%-19% of nasal epithelial cells surviving the treatment[1].


Benzalkonium chloride (0.02%) causes no abnormalities in the nasal epithelium of the monkeys after light and electron microscopical examination. In 4-5 week-old SD rats, 0.01% and 0.1% Benzalkonium chloride induce a time-dependent increase in the thickness of the nasal respiratory epithelium[1].


[1]. Johnson NF. Pulmonary Toxicity of Benzalkonium Chloride. J Aerosol Med Pulm Drug Deliv. 2017 Jul 6.