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Oxyphenisatin acetate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Oxyphenisatin acetate图片
CAS NO:115-33-3
规格:98%
分子量:401.41
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议

产品介绍
Oxyphenisatinacetate是oxyphenisatin的前体药物,过去常用作泻药。
CAS:115-33-3
分子式:C24H19NO5
分子量:401.41
纯度:98%
存储:Store at -20°C

Background:

Oxyphenisatin acetate, the pro-drug of oxyphenisatin, is used to be a laxative.


Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468. In the estrogen receptor (ER) positive MCF7 and T47D cells, oxyphenisatin acetate induces TNFα expression and TNFR1 degradation, indicating autocrine receptor-mediated apoptosis in these lines. Ten micromoles per liter Oxyphenisatin acetate treatment results in autophagy and mitochondrial dysfunction[1].


Oxyphenisatin acetate (300 mg/kg, i.p.) delivers intraperitoneally inhibited tumor growth, accompanied by phosphorylation of eIF2α and degradation of TNFR1 in an MCF7 xenograft model[1].


[1]. Morrison BL, et al. Oxyphenisatin acetate (NSC 59687) triggers a cell starvation response leading to autophagy, mitochondrial dysfunction, and autocrine TNFα-mediated apoptosis. Cancer Med. 2013 Oct;2(5):687-700.